Where in the cell is the minor spliceosome?

نویسندگان

  • Joan A Steitz
  • Gideon Dreyfuss
  • Adrian R Krainer
  • Angus I Lamond
  • A Gregory Matera
  • Richard A Padgett
چکیده

Joan A. Steitz*†, Gideon Dreyfuss‡, Adrian R. Krainer§, Angus I. Lamond¶, A. Gregory Matera , and Richard A. Padgett** *Yale University and Howard Hughes Medical Institute, New Haven, CT 06536; ‡University of Pennsylvania School of Medicine and Howard Hughes Medical Institute, Philadelphia, PA 19104-6148; §Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724; ¶University of Dundee, Dundee DD1 5EH, United Kingdom; University of North Carolina, Chapel Hill, NC 27599; and **Cleveland Clinic, Cleveland, OH 44195

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Division of Labor: Minor Splicing in the Cytoplasm

There are two molecular machineries for pre-mRNA splicing-the major spliceosome and the minor spliceosome. In this issue of Cell, König et al. (2007) demonstrate that the two splicing pathways are spatially separated in the cell and may have distinct functions.

متن کامل

A chewing proteasome is stabilized

O ne of the great surprises of modern biology was the discovery of introns and the consequent understanding that gene transcripts are spliced to form mature messenger RNA (mRNA). A further surprise was the recent discovery that there are two kinds of splicing systems, the major and minor, which act on different types of introns. and colleagues uncover yet one more surprise: the minor system act...

متن کامل

The minor spliceosome could be the major key for FUS/TLS mutants in ALS.

Despite its name, minor spliceosome alterations are often involved in human disease origin. Work by Reber et al (2016) in this issue of The EMBO Journal now demonstrates a connection between minor spliceosome components and FUS/TLS, one of the major proteins aggregating in the brain of patients affected by amyotrophic lateral sclerosis (ALS). This finding has important implications as it extend...

متن کامل

Splicing Segregation: The Minor Spliceosome Acts outside the Nucleus and Controls Cell Proliferation

The functional relevance and the evolution of two parallel mRNA splicing systems in eukaryotes--a major and minor spliceosome that differ in abundance and splicing rate--are poorly understood. We report here that partially spliced pre-mRNAs containing minor-class introns undergo nuclear export and that minor-class snRNAs are predominantly cytoplasmic in vertebrates. Cytoplasmic interference wit...

متن کامل

Computational screen for spliceosomal RNA genes aids in defining the phylogenetic distribution of major and minor spliceosomal components

The RNA molecules of the spliceosome are critical for specificity and catalysis during splicing of eukaryotic pre-mRNA. In order to examine the evolution and phylogenetic distribution of these RNAs, we analyzed 149 eukaryotic genomes representing a broad range of phylogenetic groups. RNAs were predicted using high-sensitivity local alignment methods and profile HMMs in combination with covarian...

متن کامل

Premarital Screening of Beta Thalassemia Minor in north-east of Iran

Abstract Background Beta thalassemia is a preventable disease. Iran has about 20,000Patients who are homozygote for β-thalassaemia and 3,750,000 carriers. The aim of this study was to determine the prevalence of beta thalassemia minor among men who underwent premarital screening in Quchana city in Khorasan Razavi region of Iran Materials and Methods This research is a descriptive cross-sect...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 105 25  شماره 

صفحات  -

تاریخ انتشار 2008